Partner 4: University of Paris-Sud XI [UPS], Châtenay-Malabry, France

Scientist responsible: Dr Karine Andrieux

University of Paris-Sud is one of the more famous universities in France. Our laboratory which is composed of more than 100 researchers’ incl. PhD is part of the Faculty of Pharmacy and depends also of the department of Chemical Sciences at CNRS which is the national research authority in France. This laboratory is among the top ones in France in the field of drug delivery and is very well considered internationally. Equipment for nanoparticles preparation, characterization is available (photometers, fluorimeters, HPLC, etc). The laboratory is also equipped with means for organic/polymeric synthesis, cell culture (Incubators, etc) and radioactivity experiments (Scintillation counters, etc).

Our team has elaborated stealth and functionalized polymeric nanoparticles to target the brain. Our team has an excellent background in drug formulation (encapsulation techniques), nanoparticles design (polymerization, polymeric synthesis) and in vitro evaluation (rat BBB model).

Department to carry out the work: Laboratory of Pharmaceutical Technology and Biopharmacy, UMR CNRS 8612.

More than 150 p-r papers on polymeric nanoparticles for drug delivery/ functionalization/ brain targeting (JACS, Biomacromol., Pharm Res., Eur J Neurosci., Biomaterials, etc).
Low-density lipoprotein receptormediated endocytosis of PEGylated nanoparticles in rat brain endothelial cells. Kim HR, Gil S, Andrieux K, Nicolas V, Appel M, Chacun H, Desmaele D, Taran F, Georgin D, Couvreur P. Cell Mol Life Sci., 64(3):356-64 (2007).
Squalenoyl nanomedicines as potential therapeutics. Couvreur P, Stella B, Reddy LH, Hillaireau H, Dubernet C, Desmaële D, Lepêtre-Mouelhi S, Rocco F, Dereuddre- Bosquet N, Clayette P, Rosilio V, Marsaud V, Renoir JM, Cattel L. Nano Lett. 6(11):2544-8 (2006).
Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal
antibody OX26. Aktas Y, Yemisci M, Andrieux K, Gursoy RN, Alonso MJ, Fernandez-Megia E,
Novoa-Carballal R, Quinoa E, Riguera R, Sargon MF, Celik HH, Demir AS, Hincal AA, Dalkara T,
Capan Y, Couvreur P. Bioconj. Chem. 16(6), 1503-11 (2005).

Patents: Gref R., Ponchel G., Duchene D., Couvreur P., Material based on biodegradable polymersand method for preparing same, US Patent 20040013626.

Staff involved in the Project:

Karine ANDRIEUX (35), BPharm 1996, PhD 2000, University Associate Professor since 2001. Experiences in preparation, characterization and in vitro evaluation for polymeric nanoparticles for brain drug delivery, 14 p-r papers.
Patrick COUVREUR (57) BPharm 1972, PhD 1975, Full Professor, Head of the CNRS Department since 1998. Experiences in Nanomedicine, especially in preparation, characterization and in vitro/in vivo evaluation of nanoparticles for therapeutic applications. 360 p-r papers
Experiences in Nanomedicine, especially in preparation, characterization and in vitro/in vivo evaluation of nanoparticles for therapeutic applications. 317 p-r papers.
Julien NICOLAS (29), PhD 2005, CNRS researcher since 2006, 7 p-r papers. Experiences in polymer chemistry, especially colloids and polymer/protein bioconjugates.
Hélène CHACUN (53), MS 1976, staff scientist in the laboratory since 1997 and responsible of radioactivity experiments since 1997. 14 p-r papers.

Véronique MARSAUD (41), PhD 1994, staff scientist and responsible of culture cell experiments and biological evaluation of drug loaded formulations since 1997. 14 p-r papers.

Links:

http://www.u-psud.fr/fr/index.html

http://w3.u-psud.fr/AR/70.us.html