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Partner 1: University of Milano-Bicocca [UNIMIB], Milano, Italy
Scientist responsible: Prof. Massimo Masserini (Coordinator of the project)
UNIMIB was founded ten years ago and today has 8 Faculties and 21 Departments. It has 30 thousand students attending the courses. It has two main campus, one in Milan and one other in Monza (Medical School) acting in a strict cooperation with the San Gerardo Hospital.
UNIMIB participates to NAD with a wide expertise in the areas of biochemistry, neuroscience, physiology, chemistry and physics. Instrumentations include AFM, fluorescence microscopy, dynamic laser light scattering, DSC, MS (MALDI-TOF), IR and UV-vis spectrophotometers, NMR, BiaCore, Genechip, confocal microscopy, Circular Dicroism (CD), Cytofluorimetry. Equipments for centrifugation, ultrafiltration, lyophilisation, electrophoresis, chromatography, and facilities for cell culture, protein purification and molecular biology, radiochemistry are available.
In the NAD project are involved 3 Departments:
Department of Experimental Medicine
Studies on neurochemistry, membrane biology, membrane physiology, physic-chemistry, biophysics of molecular interactions.
The personnel involved in the project are:
Massimo Masserini: Full Professor of Biochemistry; Head of DIMS; Coordinator of ‘Membranes’ Group of the Italian Society of Biochemistry;
Giuseppe Miserocchi: Full Professor of Physiology;
Giulio Sancini: Associate Researcher of Physiology;
Ilaria Rivolta: Associate Researcher of Physiology.
Expertises: membrane transports, microfluidics, nanoparticles-cell interaction, neurophysiology, biophysical and functional properties of neuronal membranes, neuropharmacology.
Francesco Mantegazza: Associate Professor of Physics;
Domenico Salerno: Researcher of Physics.
Expertises: macromolecules, complex molecular system and medical physics in general, laser light scattering.
Department of Biotechnologies and Biosciences
Studies on molecular modelling of structure and properties of biological compounds; studies on synthetic, medicinal and supramolecular chemistry, molecular recognition, enzymology and protein chemistry
The personnel involved in the project are:
Francesco Nicotra: Full Professor of Organic Chemistry; Head of BtBs; Chairman of subcommittee of Biotechnology of IUPAC; Italian representative in the International Carbohydrate Organization and in the European Carbohydrate Organization; Coordinator of the Carbohydrate Group of the Italian Chemical Society;
Barbara La Ferla: Associate Researcher of Biotechnology
Expertises: design and synthesis of biological molecules and drugs, carbohydrate microarrays to study the interaction between proteins and carbohydrates.
Department of Neurosciences and Biomedical Technologies
Studies on clinical and molecular studies on neurodegenerative diseases, neurology, neurobiology and cell biology of Alzheimer disease; synthetic organic chemistry
The personnel involved in the project are:
Carlo Ferrarese: Full Professor of Neurology; Member of Executive Committee of Italian Interdisciplinary Network of Alzheimer Disease (ITINAD);
Ildebrando Appollonio: Associate Professor of Neurology; Member of the Dementia Section of the Italian Society of Neurology (SIN-DEM).
Expertises: Clinical and neuropsychological assessment of patients with dementia, analysis of molecular mechanisms of Alzheimer disease using biological fluids and cell models.
Patents:
1) C. Battistini, et al. Fused oxabicyclic aminoalcohols as new scaffolds for combinatorial
libraries, PCT/EP2004/050350 23.02.2004, EP/11.04.03/EPA 031900991;
2) F. Nicotra, et al.. Lipid A antagonists with anti-septic shock, anti-inflammatory, anti-ischemia and analgesic activity. PCT/EP2007, 15.03.2007;
3) Cervi G., et al. "1H-PYRIDO[3,4-B]INDOL-1-ONE AND 2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLIN-1-ONE DERIVATIVES” EP07110007.7, 11 JUNE 2007.
European Experiences. FP6 (BONSAI), FP6 (GLYCIDIC SCAFFOLDS).
Pubblication before NAD:
- A.Ghetta, D.Prosperi, F.Mantegazza, L.Panza, S.Riva, T.Bellini (2005) "Light scattered by model
phantom bacteria reveals molecular interactions at their surface", P.N.A.S. USA 102 (44): 15866-
15870;
- P.Ceppi, S.Colombo, M.Francolini, F.Raimondo, N. Borghese, Masserini M. (2005) “Two tailanchored protein variants, differing in transmembrane domain length and intracellular sorting,
interact differently with lipids” P.N.A.S.USA 102, 16263-16268;
- R.Daffara, L.Botto, E.Beretta, E.Conforti, A.Faini, P.Palestini, G.Miserocchi (2004) “Endothelial
cells as early sensors of pulmonary interstitial edema” J. Appl. Physiol. 97(4):1575-83;
- F. Peri, F. Granucci, B. Costa, I. Zanoni, C. Marinzi, F. Nicotra (2007) “Non-phosphorylated
Monosaccharide Inhibits Lipid A-Induced Activation in Dendritic Cells and Macrophages” Angew.
Chem. Int. Ed. 46: 3308-3312;
- D. Maraganore, M. De Andreade, A. Elbatz, M.J. Farrer, J.P. Ioannidis, R. Krueger, W.A. Rocca,
N.K. Schneider, T.G. Lesnick, S.J. Lincoln, M.M. Hulihan, J.O. Aasly, T. Ashizawa, M.C. Chartier-Harlin, H. Checkoway, C. Ferrarese, G. Hadjigeorgiou, N. Hattori, H. Kawakami, J.C. Lambert, T. Lynch, G.D. Mellick, S. Papapetroloulos, A. Parsian, A. Quattrone, O. Riess, E.K. Tan, C. Van Broeckhoven (2006) “Collaborative Analysis of Alpha-Synuclein Gene Promoter Variability and Parkinson's Disease” Jama 296(6): 661-670
LINKS:
http://www.unimib.it/go/Home/English
http://www.dimesab.medicina.unimib.it/
http://www.btbs.unimib.it/
http://dntb.medicina.unimib.it/
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