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Partner 17: University Pierre et Marie Curies, Paris, France Scientist responsible: Prof Charles Duyckaerts
Description of our organisation:
The Neuropathology Laboratory of La Salpêtrière Hospital was created in 1964. It is both a Hospital and a University facility. For the Hospital, it is in charge of cerebral biopsies (mainly tumors), of neuromuscular biopsies (for muscle disease and peripheral neuropathy) and of post-mortem examination (of cases with neurological diseases as well as of cases dying from other diseases in the hospitals located in the Eastern part of Paris). The laboratory participates to National Networks of Brain Banks and belongs to the European Network BrainNet Europe. The laboratory is involved in teaching programs (Pierre et Marie Curie University, Paris VI) and in research. It hosts a research group "Alzheimer disease / Prions disease" co-directed by Stéphane Haïk and Charles Duyckaerts, belonging to the Research Center of the Brain and Spinal Cord Institute (ICM). The research team on Alzheimer disease includes 3 senior scientists (Charles Duyckaerts, Marie-Claude Potier and Benoît Delatour), 1 engineer (Luce Dauphinot), 2 post-doctoral students (Maï Panchal and Adina Lazar), 2 doctorate fellows (Jack Cossec and Claire Perruchini).
Publications of the Alzheimer Disease team in the last 2 years:
1: Dutheil F, Dauchy S, Diry M, Sazdovitch V, Cloarec O, Mellottee L, Bieche I, Ingelman-Sundberg M, Flinois JP, de Waziers I, Beaune P, Decleves X, Duyckaerts C, Loriot MA. Xenobiotic metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function. Drug Metab Dispos. 2009 Apr 9. [Epub ahead of print] PubMed PMID: 19359404. 2: Ceballos-Picot I, Mockel L, Potier MC, Dauphinot L, Shirley TL, Torero-Ibad R, Fuchs J, Jinnah HA. Hypoxanthine-guanine phosphoribosyl transferase regulates early developmental programming of dopamine neurons: implications for Lesch-Nyhan disease pathogenesis. Hum Mol Genet. 2009 Apr 2. [Epub ahead of print] PubMed PMID: 19342420. 3: Laffaire J, Rivals I, Dauphinot L, Pasteau F, Wehrle R, Larrat B, Vitalis T, Moldrich RX, Rossier J, Sinkus R, Herault Y, Dusart I, Potier MC. Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome. BMC Genomics. 2009 Mar 30;10(1):138. [Epub ahead of print] PubMed PMID: 19331679. 4: Duyckaerts C, Panchal M, Delatour B, Potier MC. [Morphologic and molecular neuropathology of Alzheimer's disease.]. Ann Pharm Fr. 2009 Mar;67(2):127-35. Epub 2009 Mar 5. French. PubMed PMID: 19298896. 5: Abboud H, Labreuche J, Duyckaerts C, Hauw JJ, Amarenco P. Prevalence of nephroangiosclerosis in patients with fatal stroke. Neurology. 2009 Mar 10;72(10):899-904. PubMed PMID: 19273823. 6: Alafuzoff I, Thal DR, Arzberger T, Bogdanovic N, Al-Sarraj S, Bodi I, Boluda S, Bugiani O, Duyckaerts C, Gelpi E, Gentleman S, Giaccone G, Graeber M, Hortobagyi T, Höftberger R, Ince P, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Nilsson T, Parchi P, Patsouris E, Pikkarainen M, Revesz T, Rozemuller A, Seilhean D, Schulz-Schaeffer W, Streichenberger N, Wharton SB, Kretzschmar H. Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium. Acta Neuropathol. 2009 Mar;117(3):309-20. Epub 2009 Feb 1. PubMed PMID: 19184666. 7: Blandin P, Lévêque-Fort S, Lécart S, Cossec JC, Potier MC, Lenkei Z, Druon F, Georges P. Time-gated total internal reflection fluorescence microscopy with a supercontinuum excitation source. Appl Opt. 2009 Jan 20;48(3):553-9. PubMed PMID: 19151824. 8: Mazighi M, Labreuche J, Gongora-Rivera F, Duyckaerts C, Hauw JJ, Amarenco P. Autopsy prevalence of proximal extracranial atherosclerosis in patients with fatal stroke. Stroke. 2009 Mar;40(3):713-8. Epub 2008 Dec 31. PubMed PMID: 19118247. 9: Brochard V, Combadière B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D, Callebert J, Launay JM, Duyckaerts C, Flavell RA, Hirsch EC, Hunot S. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest. 2009 Jan;119(1):182-92. doi: 10.1172/JCI36470. Epub 2008 Dec 22. PubMed PMID: 19104149; PubMed Central PMCID: PMC2613467. 10: Bensimon G, Ludolph A, Agid Y, Vidailhet M, Payan C, Leigh PN; NNIPPS Study Group. Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study. Brain. 2009 Jan;132(Pt 1):156-71. Epub 2008 Nov 23. PubMed PMID: 19029129; PubMed Central PMCID: PMC2638696. 11: Golfier G, Lemoine S, van Miltenberg A, Bendjoudi A, Rossier J, Le Crom S, Potier MC. Selection of oligonucleotides for whole-genome microarrays with semi-automatic update. Bioinformatics. 2009 Jan 1;25(1):128-9. Epub 2008 Nov 10. PubMed PMID: 19015129; PubMed Central PMCID: PMC2638942. 12: Salazar J, Mena N, Hunot S, Prigent A, Alvarez-Fischer D, Arredondo M, Duyckaerts C, Sazdovitch V, Zhao L, Garrick LM, Nuñez MT, Garrick MD, Raisman-Vozari R, Hirsch EC. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18578-83. Epub 2008 Nov 14. PubMed PMID: 19011085; PubMed Central PMCID: PMC2587621. 13: Rousseau A, Mokhtari K, Duyckaerts C. The 2007 WHO classification of tumors of the central nervous system - what has changed?. Curr Opin Neurol. 2008 Dec;21(6):720-7. PubMed PMID: 18989119. 14: Lebouvier T, Perruchini C, Panchal M, Potier MC, Duyckaerts C. Cholesterol in the senile plaque: often mentioned, never seen. Acta Neuropathol. 2009 Jan;117(1):31-4. Epub 2008 Nov 5. PubMed PMID: 18985365. 15: Lafaye P, Achour I, England P, Duyckaerts C, Rougeon F. Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation. Mol Immunol. 2009 Feb;46(4):695-704. Epub 2008 Oct 18. PubMed PMID: 18930548. 16: Delatour B, Dhenain M. [Diagnosis of Alzheimer's disease: the contribution of preclinical research]. Bull Acad Natl Med. 2008 Feb;192(2):345-60; discussion 360-1. Review. French. PubMed PMID: 18819688. 17: Duyckaerts C, Perruchini C, Lebouvier T, Potier MC. [The lesions of Alzheimer's disease: which therapeutic perspectives?]. Bull Acad Natl Med. 2008 Feb;192(2):303-18; discussion 318-21. Review. French. PubMed PMID: 18819685. 18: Altafaj X, Ortiz-Abalia J, Fernández M, Potier MC, Laffaire J, Andreu N, Dierssen M, González-García C, Ceña V, Martí E, Fillat C. Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome. Neurobiol Dis. 2008 Dec;32(3):377-84. Epub 2008 Aug 16. PubMed PMID: 18773961. 19: Duyckaerts C. Neuropathologic classification of dementias: introduction. Handb Clin Neurol. 2008;89:147-59. PubMed PMID: 18631740. 20: Duyckaerts C, Litvan I. Preface. Handb Clin Neurol. 2008;89:ix. PubMed PMID: 18631725. 3: Le Cudennec C, Faure A, Ly M, Delatour B. One-year longitudinal evaluation of sensorimotor functions in APP751SL transgenic mice. Genes Brain Behav. 2008 Feb;7 Suppl 1:83-91. PubMed PMID: 18184372. 5: Nitenberg A, Durand E, Delatour B, Sdiri W, Raha S, Lafont A. Postocclusion hyperemia provides a better estimate of coronary reserve than intracoronary adenosine in patients with coronary artery stenosis. J Invasive Cardiol. 2007 Sep;19(9):390-4. PubMed PMID: 17827509. 6: El Tayara Nel T, Volk A, Dhenain M, Delatour B. Transverse relaxation time reflects brain amyloidosis in young APP/PS1 transgenic mice. Magn Reson Med. 2007 Jul;58(1):179-84. PubMed PMID: 17659609. 7: Dhenain M, El Tannir El Tayara N, Wu TD, Guégan M, Volk A, Quintana C, Delatour B. Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice. Neurobiol Aging. 2009 Jan;30(1):41-53. Epub 2007 Jun 27. PubMed PMID: 17588710.
Links: http://english.upmc.fr/UK/info/00 http://www.chups.jussieu.fr/recherche/labos/neuropathologie/index.html
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