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Partner 19: Bial Industrial Farmacéutica S.A., Bilbao, Spain
Scientist responsible: Dr Alberto Martínez
Bial Industrial Farmacéutica, S.A. (Bial-Arístegui) is an Spanish private Company, which belongs to the Portuguese Bial Group. It is focused on the manufacturing and commercialization of allergenic extracts for diagnostic and treatment (vaccines) of allergic diseases. It has a R&D Department specialized in immunotherapy with biological products, in which several biotechnological research lines are carried out (recombinant DNA and monoclonal antibody production). Several Ethic specialities, also for human use, are commercialized, like antimicrobial agents, anti-inflammatory agents, anti-asthmatics, anti-histaminics, glucocorticoids, etc.
Bial Industrial Farmacéutica’s installations comprise the central administrative section in Madrid and the industrial unit and Research and Development Centre in Bilbao. Bial Spain produces all the group’s vaccines under very advanced technological conditions in its 2000 m2 plant. It has a staff of around 180 people, with 14 of them working in R&D Department.
PUBLICATIONS (R+D DEPARMENT):
1. ”Double-blind placebo-controlled, Alternaria alternata immunotherapy study: clinical efficacy and safety”
A.I. TABAR, M.T. LIZASO, B.E. GARCÍA, B. GÓMEZ, S. ECHECHIPÍA, M.T. ALDUNATE, B. MADARIAGA, A. MARTÍNEZ. Pediatr Allergy Immunol 2008;19:67-75.
2. ”Double-blind placebo-controlled, Alternaria alternata immunotherapy study: in vivo and in vitro parameters”
M.T. LIZASO, A.I. TABAR, B.E. GARCÍA, J.M. OLAGUIBEL, N. LABARTA, B. GÓMEZ, J. ALGORTA, J.A. ASTURIAS, A. MARTÍNEZ. Pediatr Allergy Immunol 2008;19:76-81.
3. ”Allergy to human seminal fluid: cross reactivity with dog dander”
M. BASAÑAGA, B. BARTOLOMÉ, C. PASTOR, F. TORRES, R. ALONSO, F. VIVANCO, A. CISTERÓ-BAHÍMA. J Allergy Clin Immunol 2008;121:233-9.
4. ”Esofagatis eosinofílica por sensibilización a proteínas de leche de cabra y oveja”
M. ARMISÉN, C. VIDAL, L. ROSÉS, V. RODRÍGUEZ, B. BARTOLOMÉ. Revista Española de Enfermedades Digestivas 2008;100:53-6.
5. ”Expression of a recombinant protein immunochemical equivalent to the major Anisakis simplex allergen Ani s 1”
I. IBARROLA, M.C. ARILLA, M.D. HERRERO, M.I. ESTEBAN, A. MARTÍNEZ, J.A. ASTURIAS. J Investig Allergol Clin Immunol 2008;18:78-83.
6. ”Vine pollen allergy in areas with a high density of vineyards”
F. FEO, P. MUR, B. BARTOLOMÉ, A. M. ALONSO, P. LARA, J.A. FERNÁNDEZ, A. MARTÍNEZ. Ann Allergy Asthma Immunol 2008;100:596-600.
7. ”Occupational rhinitis and asthma due to crickets”
T. LINARES, D. HERNÁNDEZ, B. BARTOLOMÉ. Ann Allergy Asthma Immunol 2008;100:566-569.
8. ”An antibody-based ELISA for quantification of Ani s 1, a termoestable antigen of Anisakis simplex”
M.C. ARILLA, I. IBARROLA, A. MARTÍNEZ, J. MONTESEIRÍN, J. CONDE, J.A. ASTURIAS. Parasitol 2008;135:735-740.
9. ”Allergy to laxative compound (Plantago ovata seed) among health care professionals”
N. BERNEDO, M. GARCÍA, G. GASTAMINZA, E. FERNÁNDEZ, B. BARTOLOMÉ, J. ALGORTA, D. MUÑOZ. J Investig Allergol Clin Immunol 2008;18:181-189.
10. “Adverse reactions to the processionary caterpillar: irritant or allergic mechanism?”
S. SANTOS, D. GONZÁLEZ, B. BARTOLOMÉ, M..J. TRUJILLO, A. MENÉNDEZ, E. GONZÁLEZ. Contact Dermatitis 2008;59:1-2
11. ”An approach to the knowledge of pollen and allergen diversity through lipid transfer protein localisation in taxonomically distant pollen grains”
MARÍA SUÁREZ-CERVERA, ANA VEGA-MARAY, TERESA CASTELLS, F. JAVIER RODRÍGUEZ-RAJO, JUAN A. ASTURIAS, ANNICK LE THOMAS & JUAN A. SEOANE-CAMBA. Grana 2008; 47:272-284
12. ”Allergy to iguana”
P. GONZALEZ-DELGADO, V. SORIANO GOMIS, B. BARTOLOME, E. NIVEIRO HERNÁNDEZ. Allergol et Immunopathol 2008;36 (5):311-2.
13. “Par j 1 and Par j 2, the two major allergens in Parietaria judaica, bind preferentially to monoacylated negative lipids”
ROBERTO GONZALEZ-RIOJA, JUAN A. ASTURIAS, ALBERTO MARTÍNEZ, FÉLIX M. GOÑI, ANA ROSA VIGUERA. FEBS Journal 276 (2009); 1762-1775.
14. ”Recombinant hypoallergens for immunotherapy of Parietaria judaica pollen allergy”
J.A. ASTURIAS. Frontiers in Bioscience, 2009 (in press).
15. “Bird-egg syndrome caused by Agapornis spp”
F. VILLAS, E. COMPES, M. FERNÁNDEZ, M.P. MUÑOZ, B. BARTOLOMÉ, M. DE LAS HERAS. J Investig Allerol Clin Immunol 2009 (in press).
16. “Urticaria-angioedema due to limpet ingestion”
D. GUTIÉRREZ, M.S. FUENTES, B. BARTOLOMÉ, A. FONCUBIERTA, J. LUCAS, A. LEÓN. J Investig Allergol Clin Immunol 2009 (in press).
17. “Severe allergy to poultry meat without sensitization to egg proteins with concomitant Leguminosae allergy. Case report”
ANNA SOKOLOVA, ANA CÉLIA COSTA, MARIA CONCEIÇAO SANTOS, BORJA BARTOLOMÉ, MANUEL PEREIRA BARBOSA. Allergologia et Immunopathologia 2009 (in press).
Our website: www.bial.com
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